MANIAC, Netflix’s Original Limited Series from Cary Joji Fukunaga, tells the story of two strangers who find themselves in a mysterious pharmaceutical trial. Things start to unravel for Annie Lansberg (Emma Stone) and Owen Milgrim (Jonah Hill), as they start to bounce from one fantasy world to the next. MANIAC’s 10-episode series arrives on Netflix September 21. Watch the first official trailer above.